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Nigerian Institute of Medical Research – COVID-19 Fractional Dosing Trial

Photo courtesy of the Nigerian Institute of Medical Research.
Award Date 
1/2022
Grant Amount 
$2,921,000
Purpose 
To support immunogenicity trials of fractional doses of the Moderna, AstraZeneca, and J&J COVID vaccines in Nigeria.
Topic (focus area) 

Grant Investigator: Jacob Trefethen

This page was reviewed but not written by the grant investigator. Nigerian Institute of Medical Research staff also reviewed this page prior to publication.

Open Philanthropy recommended a grant of $2,921,000 to the Nigerian Institute of Medical Research to support a safety and immunogenicity trial in adults in Nigeria of fractional doses of the AstraZeneca, Moderna, and Johnson & Johnson COVID-19 vaccines. The trial has the potential to indicate that doses of these vaccines that are a quarter or half the size of standard doses promote “non-inferior” immune responses. If non-inferiority can be established, this could allow many people to be vaccinated against COVID-19 sooner despite limited supplies, reducing deaths and other harms from the pandemic.

This falls within our work on scientific research, and specifically within our interest in science supporting biosecurity and pandemic preparedness.