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Human Health and Wellbeing

Disease and premature death are a major source of suffering. Treatments now potentially within reach may extend the human healthspan and improve quality of life. We aim to support tractable and cost-effective research on the world’s most burdensome diseases, including heart disease, cancer, malaria, and others. In addition to the grants listed here, Open Philanthropy Scientific Research staff advises Good Ventures on research related to Alzheimer’s disease.

Our Work

Grant 1/2018

This multicenter clinical trial of a new therapy for severe sepsis will be led by Dr. Michael Donnino of Harvard. Sepsis is a significant cause of mortality in the United States and worldwide, resulting in an estimated 5.3 million deaths annually.

Press 4/2019
from The Sacramento Bee

EicOsis cleared a key regulatory hurdle with the U.S. Food and Drug Administration and expects to launch human trials later this year. Open Philanthropy has invested in EicOsis.

Grant 2/2019

The Open Philanthropy Project recommended a grant of $1,134,975 to the University Health Network, a Canadian research center affiliated with the University of Toronto, to support a randomized controlled trial investigating the efficacy of an intervention to reduce preterm birth in Malawi.

Grant 1/2019

The Open Philanthropy Project recommended a grant of $333,550 to the Center for Global Development for research on the assessment and regulation of gene drive technology.

Grant 11/2018

The Open Philanthropy Project recommended an investment of $5,000,000 in EicOsis to support clinical trials on a novel, non-opioid, oral therapy for neuropathic and inflammatory pain.

Press 11/2018
from The Economist

Target Malaria carries the prospect of huge humanitarian gains. It’s carefully designed, supported by Open Phil and the Gates Foundation, being carried out under international scrutiny, and gaining political support and inspiring a generation of researchers.

Grant 10/2018

The Open Philanthropy Project recommended $1,044,501 to the CDC Foundation to support work on the cryopreservation of mosquito larvae which could make it easier for researchers conduct field trials related to malaria prevention.

Press 9/2018
from STAT

Burkina Faso granted scientists permission to release genetically engineered mosquitoes. It’s a key step in the broader efforts to use bioengineering to eliminate malaria in the region.

This work was driven by our grantee Target Malaria.