• Focus Areas
    • Cause Selection
    • Global Health & Wellbeing
      • Effective Altruism Community Growth (Global Health and Wellbeing)
      • Farm Animal Welfare
      • Global Aid Policy
      • Global Health & Development
      • Scientific Research
      • South Asian Air Quality
    • Longtermism
      • Biosecurity & Pandemic Preparedness
      • Effective Altruism Community Growth (Longtermism)
      • Potential Risks from Advanced AI
    • Other Areas
      • Criminal Justice Reform
      • History of Philanthropy
      • Immigration Policy
      • Land Use Reform
      • Macroeconomic Stabilization Policy
  • Grants
  • Research & Updates
    • Research Reports
    • Blog Posts
    • Notable Lessons
    • In the News
  • About Us
    • Grantmaking Process
    • How to Apply for Funding
    • Team
    • Contact Us
    • Stay Updated
  • We’re hiring!
  • Focus Areas
    • Cause Selection
    • Global Health & Wellbeing
      • Effective Altruism Community Growth (Global Health and Wellbeing)
      • Farm Animal Welfare
      • Global Aid Policy
      • Global Health & Development
      • Scientific Research
      • South Asian Air Quality
    • Longtermism
      • Biosecurity & Pandemic Preparedness
      • Effective Altruism Community Growth (Longtermism)
      • Potential Risks from Advanced AI
    • Other Areas
      • Criminal Justice Reform
      • History of Philanthropy
      • Immigration Policy
      • Land Use Reform
      • Macroeconomic Stabilization Policy
  • Grants
  • Research & Updates
    • Research Reports
    • Blog Posts
    • Notable Lessons
    • In the News
  • About Us
    • Grantmaking Process
    • How to Apply for Funding
    • Team
    • Contact Us
    • Stay Updated
  • We’re hiring!

Purdue University — Preclinical Data Research (Douglas Brubaker)

Visit Grantee Site
  • Portfolio Area: Scientific Innovation: Tools and Techniques
  • Focus Area: Scientific Research
  • Organization Name: Purdue University
  • Amount: $1,500,000

  • Award Date: August 2021

Table of Contents


    Grant investigators: Heather Youngs and Chris Somerville

    This page was reviewed but not written by the grant investigators. Purdue University staff also reviewed this page prior to publication.


    Open Philanthropy recommended a grant of $1,500,000 over five years to Purdue University to support research led by Dr. Douglas Brubaker on developing a computational model to translate preclinical data in mouse disease models to humans. It is not uncommon that preclinical data from mice fail to translate to similar preclinical results in humans, limiting the applicability of mouse data to human medicine. Dr. Brubaker intends to use this funding to develop a computational model that uses mouse data from an Alzheimer’s disease study conducted by Washington University to attempt to predict the study’s human trial outcomes. Good Ventures, Cari Tuna and Dustin Moskovitz’s foundation, has provided funding for the Washington University study. The foundation, with support from Open Philanthropy, has been investigating how best to fund scientific research that might help reduce the future burden of Alzheimer’s disease. Our scientific research team believes that Dr. Brubaker’s computational model, if successful, could improve drug discovery and reduce reliance on mouse experiments.

    This falls within our work on scientific research, specifically within our interest in advancing tools and techniques.

    Expand Footnotes Collapse Footnotes

    1.https://www.nature.com/articles/nrd3078

    2.Good Ventures, Cari Tuna and Dustin Moskovitz’s foundation, has provided funding for the Washington University study. The foundation, with support from Open Philanthropy, has been investigating how best to fund scientific research that might help reduce the future burden of Alzheimer’s disease.

    Related Items

    • Scientific Innovation: Tools and Techniques

      University of Notre Dame — Nanopore Protein Sequencing (Gregory Timp) (2021)

      Open Philanthropy recommended a grant of $1,769,056 over two years to the University of Notre Dame to continue support for Dr. Gregory Timp’s work developing an instrument that...

      Read more
    • Scientific Innovation: Tools and Techniques

      University of California, Los Angeles — Social Science Genetic Association Consortium (2020)

      Open Philanthropy recommended a grant of $2,250,000 to the University of California, Los Angeles, to support the Social Science Genetic Association Consortium (SSGAC). Our understanding is that SSGAC...

      Read more
    • Scientific Innovation: Tools and Techniques

      Duke University — CRISPR-Based Epigenome Editing Tools (Charles Gersbach)

      The Open Philanthropy Project recommended a grant of $2,550,171 over three years to Duke University to develop tools to apply epigenome editing to refine genome wide association studies...

      Read more
    Back to Grants Database
    Open Philanthropy
    Open Philanthropy
    • Careers
    • Press Kit
    • Governance
    • Privacy Policy
    • Stay Updated
    Mailing Address
    Open Philanthropy
    182 Howard Street #225
    San Francisco, CA 94105
    Email
    [email protected]
    Media Inquiries
    [email protected]
    Anonymous Feedback
    Feedback Form

    © Open Philanthropy 2022 Except where otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial 4.0 International License. If you'd like to translate this content into another language, please get in touch!