Open Philanthropy recommended a grant of $2,000,000 to 1Day Sooner for general support. 1Day Sooner’s mission is to advocate on behalf of volunteers for human challenge trials (HCTs). They hope to accelerate the development of vaccines for several neglected diseases by organizing volunteers to take part in HCTs, and by advocating for the use of regulatory and financial tools like advance market commitments.
HCTs, which involve exposing volunteers to a controlled dose of a pathogen, require fewer participants and can be completed on a significantly shorter timeline than standard clinical trials. They have historically been used for smallpox, influenza, malaria, and other potentially fatal diseases.